Preventive Effect of Diabegon, a Polyherbal Preparation, During Progression of Diabetes Induced by High-Fructose Feeding in Rats
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- Yadav Hariom
- School of Studies in Biochemistry, Jiwaji University, India
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- Jain Shalini
- Animal Biochemistry Division, National Dairy Research Institute, India
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- Prasad GBKS
- School of Studies in Biochemistry, Jiwaji University, India
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- Yadav Mukesh
- School of Studies in Chemistry, Jiwaji University, India
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In the present study, the polyherbal preparation diabegon, containing 18 plant extracts with hypoglycemic activity, was evaluated for its preventive effect during progression of type 2 diabetes in high-fructose-diet–fed rats. Oral administration of diabegon (100 mg/kg body weight) delayed development of glucose intolerance for 4 weeks in comparison with the diabetic control group, and the effect of diabegon was compared to that of the standard insulin sensitizer drug rosiglitazone. Diabegon treatment also ameliorated the elevation of glycosylated haemoglobin, liver glycogen content, plasma insulin, homeostasis model assessment, free fatty acids, triglycerides, total cholesterol, LDL-cholesterol, and VLDL-cholesterol, whereas it increased HDL-cholesterol after 56 days of treatment (P<0.05). The mechanism of action by which diabegon attenuates insulin resistance and dyslipidemia may be through induction of peroxisome proliferator-activated receptor-γ and lipoprotein lipase activity in peripheral tissues (muscles). Moreover, diabegon administration for 56 days also produced no alteration in liver and kidney function tests, which seems to indicate its non-toxicity during treatment. Our present results suggest that diabegon may be included in diabetes mellitus treatment regimens, as a drug with good antidiabetic actions but no toxic manifestations.<br>
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 105 (1), 12-21, 2007
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282680155016832
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- NII論文ID
- 10024315520
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- NII書誌ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 8918616
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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