N-Acetyl-L-Cysteine Inhibits Marble-Burying Behavior in Mice

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  • Egashira Nobuaki
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan Department of Pharmacy, Kyushu University Hospital, Japan Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan Department of Pharmacy, Kyushu University Hospital, Japan
  • Shirakawa Atsunori
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
  • Abe Moe
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
  • Niki Tomiko
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
  • Mishima Kenichi
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
  • Iwasaki Katsunori
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
  • Oishi Ryozo
    Department of Pharmacy, Kyushu University Hospital, Japan Department of Pharmacy, Kyushu University Hospital, Japan
  • Fujiwara Michihiro
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan

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  • <I>N</I>-Acetyl-L-Cysteine Inhibits Marble-Burying Behavior in Mice

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In the present study, we examined the effect of N-acetyl-L-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. On the other hand, the antioxidant α-tocopherol (10, 30, and 100 mg/kg, p.o.) had no effect on the marble-burying behavior. These results suggest that the glutamatergic system is involved in the marble-burying behavior, and NAC may be useful for treatment of OCD.

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