New Topics in Vasopressin Receptors and Approach to Novel Drugs:<br>Involvement of Vasopressin V1a and V1b Receptors in Nociceptive Responses and Morphine-Induced Effects

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  • Honda Kenji
    Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
  • Takano Yukio
    Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan

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  • Involvement of vasopressin V1a and V1b receptors in nociceptive responses and morphine-induced effects
  • New Topics in Vasopressin Receptors and Approach to Novel Drugs: Involvement of Vasopressin V1a and V1b Receptors in Nociceptive Responses and Morphine-Induced Effects

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Abstract

Arginine vasopressin (AVP) receptors have been classified into V1a, V1b, and V2 subtypes. Recent studies have demonstrated the involvement of AVP in anti-nociception and in morphine-induced anti-nociception. However, the roles of individual AVP-receptor subtypes have not been fully elucidated. Here, we have summarized the role of V1-receptor subtypes in behavioral responses to noxious stimuli and to morphine. In this review, we focus on studies using mice lacking the V1a receptor (V1a−/− mice) and the V1b receptor (V1b−/− mice).<br>

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