Evidence for Separate Involvement of Different .MU.-Opioid Receptor Subtypes in Itch and Analgesia Induced by Supraspinal Action of Opioids

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  • Andoh Tsugunobu
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
  • Yageta Yuichi
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
  • Konno Mitsuhiro
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
  • Yamaguchi-Miyamoto Tomomi
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
  • Takahata Hiroki
    Department of Organic and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, Japan
  • Nojima Hiroshi
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Ohu University, Japan
  • Nemoto Hideo
    Laboratory of Medical Chemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
  • Kuraishi Yasushi
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan 21st Century COE Program, University of Toyama, Japan

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  • Evidence for separate involvement of different μ-opioid receptor subtypes in itch and analgesia induced by supraspinal action of opioids
  • Evidence for separate involvement of different m opioid receptor subtypes in itch and analgesia induced by supraspinal action of opioids

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Abstract

The common adverse effect of centrally-injected μ-opioid receptor (μ-OR) agonists is pruritus. This study was conducted using mice to examine whether different subtypes of μ-OR would be responsible for pruritus and analgesia. Intracisternal injections of morphine and morphine-6β-glucronide (M6G), but not M3G, produced an antinociceptive effect. Morphine, but neither M6G nor M3G, induced facial scratching, a pruritus-related response. Facial scratching following morphine was not affected by the μ1-OR antagonist naloxonazine at doses that inhibited the antinociceptive effects. The results suggest that different subtype and/or splice variants of μ-OR are separately involved in pruritus and antinociception of opioids.<br>

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