Protective Effect of Neurotrophic Agent T-817MA Against Inner Ear Barotrauma in the Guinea Pig
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- Maekawa Hitoshi
- Department of Otolaryngology, National Defense Medical College, Japan
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- Matsunobu Takeshi
- Department of Otolaryngology, National Defense Medical College, Japan
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- Satoh Yasushi
- Department of Anesthesiology, National Defense Medical College, Japan
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- Kurioka Takaomi
- Department of Otolaryngology, National Defense Medical College, Japan
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- Nakamura Asako
- Research Laboratories, Toyama Chemical Co., Ltd., Japan
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- Iwakami Noboru
- Research Laboratories, Toyama Chemical Co., Ltd., Japan
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- Shiotani Akihiro
- Department of Otolaryngology, National Defense Medical College, Japan
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Description
T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}azetidin-3-ol maleate), a neurotrophic compound newly synthesized for the treatment of Alzheimer’s disease, has been found to reduce oxidative stress and exert neuroprotective effects. By assessing the auditory functioning and observing the cochlear sensory epithelia, we investigated whether T-817MA protects the cochlea from inner ear barotrauma in guinea pigs treated with rapidly intense pressure change. Sustained oral administration of T-817MA significantly reduced the extent of auditory threshold shifts and outer hair cell loss, indicating that T-817MA attenuates the intense pressure–induced cochlear damage that accompanies inner ear barotrauma via antioxidative activity.
Journal
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 117 (1), 67-70, 2011
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390282680155449600
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- NII Article ID
- 10029896029
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- NII Book ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL BIB ID
- 11243237
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- PubMed
- 21869565
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- JaLC
- NDL Search
- Crossref
- CiNii Articles
- KAKEN
- OpenAIRE
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- Abstract License Flag
- Disallowed
