The Cannabinoid 1-Receptor Silent Antagonist O-2050 Attenuates Preference for High-Fat Diet and Activated Astrocytes in Mice
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- Higuchi Sei
- Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
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- Irie Keiichi
- Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan Advanced Materials Institute, Fukuoka University, Japan
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- Mishima Shohei
- Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
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- Araki Maiko
- Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
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- Ohji Makiko
- Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
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- Shirakawa Atsunori
- Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
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- Akitake Yoshiharu
- Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan Advanced Materials Institute, Fukuoka University, Japan
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- Matsuyama Kiyoshi
- Department of Chemical Engineering, Faculty of Engineering, Fukuoka University, Japan
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- Mishima Kenji
- Department of Chemical Engineering, Faculty of Engineering, Fukuoka University, Japan
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- Mishima Kenichi
- Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan Advanced Materials Institute, Fukuoka University, Japan
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- Iwasaki Katsunori
- Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan Advanced Materials Institute, Fukuoka University, Japan
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- Fujiwara Michihiro
- Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
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Endocannabinoids have been shown to activate reward-related feeding and to promote astrocytic differentiation. We investigated whether high-fat diet (HFD) intake produced a preference for HFD via an endocannabinoid-dependent mechanism. In the conditioned place preference test, the 2-week HFD–intake group showed preference for HFD and had increased expression of a marker for reactive astrocytes, glial fibrillary acid protein (GFAP), in the hypothalamus. The cannabinoid CB1–receptor antagonist O-2050 reduced the preference for HFD and expression of GFAP in the hypothalamus. These results suggested that HFD intake led to the development of a preference for HFD via astrocytic CB1 receptors in the hypothalamus.
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 112 (3), 369-372, 2010
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282680155590016
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- NII論文ID
- 10027744701
- 130000164306
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- NII書誌ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 10606973
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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