Activation of Adrenergic β Receptor by Free FattyAcid Composition
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- NAKANO Yuka
- Department of Chemistry, Rikkyo Univerisy, 3-34-1 Nishi-Ikebukuro, Toshima, Tokyo 171-8501 Japan
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- KAWASE Saki
- Department of Chemistry, Rikkyo Univerisy, 3-34-1 Nishi-Ikebukuro, Toshima, Tokyo 171-8501 Japan
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- SANDOU Ayumi
- Department of Chemistry, Rikkyo Univerisy, 3-34-1 Nishi-Ikebukuro, Toshima, Tokyo 171-8501 Japan
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- TOKIWA Hiroaki
- Department of Chemistry, Rikkyo Univerisy, 3-34-1 Nishi-Ikebukuro, Toshima, Tokyo 171-8501 Japan
Bibliographic Information
- Other Title
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- 遊離脂肪酸混合物による β アドレナリン受容体の活性化
- ユウリ シボウサン コンゴウブツ ニ ヨル vアドレナリン ジュヨウタイ ノ カッセイカ
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Abstract
We report the novel molecular mechanism of activation of the adrenergic β receptor by free fatty acid composition based on the activated experimental structure of the receptor. Dimers of adrenergic β receptors have been stably formed due to sandwich structure between cholesterols and free fatty acids. Stabilization of the dimer formation enhanced signal communication initiated by the ligand binding.
Journal
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- Journal of Computer Chemistry, Japan
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Journal of Computer Chemistry, Japan 11 (2), 121-124, 2012
Society of Computer Chemistry, Japan
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Details 詳細情報について
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- CRID
- 1390282680156034304
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- NII Article ID
- 130001908179
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- NII Book ID
- AA11657986
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- ISSN
- 13473824
- 13471767
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- NDL BIB ID
- 024235519
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed