Construction of a Growing Information-Community for Teratogenic Agents

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  • YAMAUCHI Aiko
    Department of Pharmaceutical Information Science, Graduate School of Pharmaceutical Science, The University of Tokushima
  • NAKATA DOOLIN Eiko
    Department of Pharmacy, NTT-East Kanto Medical Center
  • CHUMAN Hiroshi
    Division of Analytical Chemistry, Faculty of Pharmaceutical Sciences, The University of Tokushima

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Other Title
  • 双方向・成長型薬物催奇形性情報コミュニティの構築
  • ソウホウコウ セイチョウガタ ヤクブツ サイキケイ セイジョウホウ コミュニティ ノ コウチク

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Congenital malformations or birth defects are a major public concern. However, lack of proper information may panic a pregnant woman who had taken medicines without noticing the pregnancy, and thus may result in an unnecessary abortion. We have undertaken a new research/development project to create an information-community for teratogenic agents, consisting of pregnant women, pharmacists, physicians and research scientists working on medicinal products. We have designed a trial database system for teratogenic agents. The database performs not only retrieval of teratogenic information and chemical structures of drugs/medicinal products, but also registration of clinical case reports and teratogenic information on various chemicals. Our system will be useful for clinical risk-assessment of teratogenic exposures in pregnant women and for the development of new drugs based on chemical information and computer science.

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