Involvement of Histamine Released From Mast Cells in Acute Radiation Dermatitis in Mice
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- Moriyasu Saiko
- Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Japan
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- Yamamoto Kouichi
- Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Japan
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- Kureyama Naoko
- Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Japan
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- Okamura Keita
- Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Japan
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- Ikeda Toshiji
- Department of Accelerator Science, The Institute of Scientific and Industrial Research, Osaka University, Japan
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- Yamatodani Atsushi
- Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Japan
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説明
A possible involvement of histamine in acute radiation dermatitis in mice was investigated. The dose of 40 Gy of gamma irradiation induced erythema and edema in C57BL/6 mice treated with vehicle. However, in C57BL/6 mice treated with chlorpheniramine and WBB6F1-W/Wv mice, erythema and edema were not observed. In all of these mice, epilation and dry desquamation were induced, but bepotastine significantly reduced the extent of these areas. These results suggest that gamma irradiation-induced erythema and edema were caused by histamine released from mast cells via histamine H1 receptor, and epilation was induced by other inflammatory mediators.<br>
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 104 (2), 187-190, 2007
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282680156457728
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- NII論文ID
- 10024314546
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- NII書誌ID
- AA11806667
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- COI
- 1:STN:280:DC%2BD2sznslCitg%3D%3D
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 8781944
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 使用不可