Antioxidant, free radical-scavenging, and NF-кB-inhibitory activities of phytosteryl ferulates: structure-activity studies

DOI Web Site PubMed 被引用文献13件 参考文献73件 オープンアクセス
  • Islam Md. Shafiqul
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
  • Yoshida Hiroshi
    Department of Veterinary Clinical Pathobiology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
  • Matsuki Naoaki
    Department of Veterinary Clinical Pathobiology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
  • Ono Kenichiro
    Department of Veterinary Clinical Pathobiology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
  • Nagasaka Reiko
    Department of Food Science and Technology, Tokyo University of Marine Science and Technology, Japan
  • Ushio Hideki
    Department of Food Science and Technology, Tokyo University of Marine Science and Technology, Japan
  • Guo Ying
    Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Japan
  • Hiramatsu Toshiyuki
    Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Japan
  • Hosoya Takamitsu
    Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Japan
  • Murata Takahisa
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
  • Hori Masatoshi
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
  • Ozaki Hiroshi
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan

書誌事項

タイトル別名
  • Antioxidant, Free Radical-Scavenging, and NF-.KAPPA.B-Inhibitory Activities of Phytosteryl Ferulates: Structure-Activity Studies
  • Antioxidant free radical scavenging and NF kB inhibitory activities of phytosteryl ferulates structure activity studies
  • Antioxidant, Free Radical–Scavenging, and NF-κB–Inhibitory Activities of Phytosteryl Ferulates: Structure–Activity Studies

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説明

Some of the pharmacological properties of phytosteryl ferulates may be linked to their antioxidant potential. In this study, 2,2-diphenyl-1-picrylhydrazyl (DPPH), electron spin resonance (ESR), and thiobarbituric acid–reactive substances (TBARS) assays demonstrated that phytosteryl ferulates such as cycloartenyl ferulate (CAF), 24-methylenecycloartanyl ferulate (24-mCAF), and β-sitosteryl ferulate (β-SF) and ferulic acid (FA) each exerted strong free radical scavenging and antioxidation of lipid membrane, which were comparable to α-tocopherol. However, the sterol moiety alone, such as cycloartenol (CA), had neither activity. Since, the reactive oxygen species (ROS) production in the cell complex defense mechanism cannot be ruled out with the cell free system, we measured ROS production in NIH 3T3 fibroblast cells induced by H2O2. CAF and ethyl ferulate (eFA) greatly decreased the ROS level in this system. CA also significantly inhibited the ROS level, suggesting that CA could inhibit ROS production in living cells. Besides these, CAF, 24-mCAF, β-SF, as well as eFA and CA, all these chemicals significantly inhibited the NF-κB activity as analyzed by measuring translocation of NF-κB p65 in LPS-stimulated RAW 264.7 macrophages. These observations revealed that phytosteryl ferulates are responsible for the antioxidant and anti-inflammatory activity via ROS scavenging and inhibition of ROS production.<br>

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