Involvement of the Na+/Ca2+ Exchanger in the Automaticity of Guinea-Pig Pulmonary Vein Myocardium as Revealed by SEA0400

DOI Web Site PubMed 25 Citations 28 References Open Access
  • Namekata Iyuki
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
  • Tsuneoka Yayoi
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
  • Takahara Akira
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
  • Shimada Hideaki
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
  • Sugimoto Takahiko
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
  • Takeda Kiyoshi
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
  • Nagaharu Midori
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
  • Shigenobu Koki
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
  • Kawanishi Toru
    Division of Drugs, National Institute of Health Sciences, Japan
  • Tanaka Hikaru
    Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan

Bibliographic Information

Other Title
  • Short Communication Involvement of the Na+/Ca 2+ Exchanger in the Automaticity of Guinea-Pig Pulmonary Vein Myocardium as Revealed by SEA0400

Search this article

Description

We examined the involvement of the Na+/Ca2+ exchanger in the automaticity of the pulmonary vein myocardium with a specific inhibitor, SEA0400. Action potentials were recorded from the myocardial layer of isolated guinea-pig pulmonary vein preparations, and Ca2+ transients were recorded from the cardiomyocytes. Spontaneous electrical activity was observed in 17.7% of the preparations, which was inhibited by either SEA0400 or ryanodine. In quiescent preparations, ouabain induced electrical activity and spontaneous Ca2+ transients, which were inhibited by SEA0400, as well as ryanodine. These results provide pharmacological evidence that the Na+/Ca2+ exchanger underlies the automaticity of the pulmonary vein myocardium.<br>

Journal

Citations (25)*help

See more

References(28)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top