Contrasting Dose-Effects of Multi-glycoside of Tripterygium wilfordii HOOK. f. on Glomerular Inflammation and Hepatic Damage in Two Types of Anti-Thy1.1 Glomerulonephritis

DOI Web Site PubMed 被引用文献2件 参考文献68件
  • Wan Yi-Gang
    Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, China Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, China
  • Zhao Qing
    Department of Graduate School, Nanjing University of Chinese Medicine, China Department of Graduate School, Nanjing University of Chinese Medicine, China
  • Sun Wei
    Department of Nephrology, Jiangsu Provincial Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, China Department of Nephrology, Jiangsu Provincial Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, China
  • Zhang Hui-Lan
    Oriental Academy of Chinese Medicine, Malaysia Oriental Academy of Chinese Medicine, Malaysia
  • Li Min
    Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, China Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, China
  • Wei Qing-Xue
    Department of Graduate School, Nanjing University of Chinese Medicine, China Department of Graduate School, Nanjing University of Chinese Medicine, China
  • Wu Wei
    Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, China Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, China
  • Yue Li-Jun
    Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, China Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, China
  • Wang Qing
    Department of Graduate School, Nanjing University of Chinese Medicine, China Department of Graduate School, Nanjing University of Chinese Medicine, China

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  • Contrasting Dose–Effects of Multi-glycoside of <I>Tripterygium wilfordii</I> HOOK. f. on Glomerular Inflammation and Hepatic Damage in Two Types of Anti-Thy1.1 Glomerulonephritis

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Multi-glycoside, one of the extracted compounds from Tripterygium wilfordii HOOK. f. (GTW), has been shown to be clinically effective in suppressing glomerular inflammation in chronic kidney disease. However, its clinical application is often limited by its cytotoxic actions on the liver. This study was performed to contrast the dose–effects of GTW on glomerular inflammation and hepatic damage in two types of anti-Thy1.1 glomerulonephritis (GN). Rats with acute or chronic anti-Thy1.1 GN were either left untreated (the Vehicle group) or treated with a high or low dose of GTW and sacrificed on day 7 or day 45. GTW was administrated 3 days before or at the same time as the antibody injection and lasted until sacrifice. GTW at high dose ameliorated glomerular macrophage accumulation, mesangial proliferation, proteinuria, and interleukin-2 expression in the acute anti-Thy1.1 GN model, but caused structural and functional lesions in the liver. In contrast, GTW at low dose improved activated macrophage and T lymphocyte infiltration, mesangial injury, proteinuria, and interleukin-2 and interferon-γ expressions without hepatic toxicity in the chronic model of GN induced by anti-Thy1.1 antibody. In conclusion, GTW at low dose not only effectively inhibits glomerular inflammation but also avoids severe injuries to the liver.

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