Anticonvulsant Effects of Fuzi Total Alkaloid on Pentylenetetrazole-Induced Seizure in Mice

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  • Li Bingjin
    National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
  • Tang Fang
    National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
  • Wang Liang
    National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
  • Liu Lei
    National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
  • Zhao Jing
    National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
  • Zhou Yang
    National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
  • Wang Yinuo
    National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
  • Song Yunong
    National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
  • Li Yuxin
    National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
  • Cui Ranji
    National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China Jilin Key Laboratory of Animal Resource Conservation and Utilization, School of Life Sciences, Northeast Normal University, China

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We investigated the anticonvulsant effect of acute Fuzi total alkaloid (FTA) in seizure induced by the GABAA-receptor antagonist pentylenetetrazole (PTZ). FTA significantly increased the seizure latency and decreased the mortality in PTZ-treated mice. Administration of PTZ increased c-Fos expression in the hippocampus, medial prefrontal cortex, and piriform cortex; and this PTZ-induced effect was inhibited by FTA in a dose-dependent manner. Furthermore, the effects of FTA on PTZ-induced seizure and c-Fos expression were reversed by the GABAA/benzodiazepine receptor–selective antagonist flumazenil. These findings suggest that the anticonvulsant effects of FTA may be related to modulation of GABAA–benzodiazepine receptor complex.

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