Metaplastic Regulation of the Median Raphe Nucleus via Serotonin 5-HT₁A Receptor on Hippocampal Synaptic Plasticity Is Associated With Gender-Specific Emotional Expression in Rats

DOI Web Site Web Site PubMed 被引用文献2件 参考文献69件 オープンアクセス
  • Inoue Sumitaka
    Department of Pharmacology, Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan
  • Shikanai Hiroki
    Department of Pharmacology, Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan
  • Matsumoto Machiko
    Department of Pharmacology, Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan
  • Hiraide Sachiko
    Department of Pharmacology, Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan
  • Saito Yasuhiro
    Department of Pharmacology, Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan
  • Yanagawa Yoshiki
    Department of Pharmacology, Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan
  • Yoshioka Mitsuhiro
    Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Japan
  • Shimamura Kei-ichi
    Department of Pharmacology, Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan
  • Togashi Hiroko
    Department of Pharmacology, Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan

書誌事項

タイトル別名
  • Metaplastic Regulation of the Median Raphe Nucleus via Serotonin 5-HT<sub>1A</sub> Receptor on Hippocampal Synaptic Plasticity Is Associated With Gender-Specific Emotional Expression in Rats

この論文をさがす

説明

Gender differences in psychiatric disorders are considered to be associated with the serotonergic (5-HTergic) system; however the underlying mechanisms have not been clearly elucidated. In this study, possible involvement of the median raphe nucleus (MRN)-hippocampus 5-HTergic system in gender-specific emotional regulation was investigated, focusing on synaptic plasticity in rats. A behavioral study using a contextual fear conditioning (CFC) paradigm showed that the females exhibited low anxiety-like behavior. Extracellular 5-HT levels in the hippocampus were increased by CFC only in the males. Long-term potentiation (LTP) in the hippocampal CA1 field was suppressed after CFC in the males, which was mimicked by the synaptic response to MRN electrical stimulation. In the MRN, 5-HT immunoreactive cells significantly increased in the females compared with those in the males. Pretreatment with the 5-HT1A receptor agonists tandospirone (10 mg/kg, i.p.) and 8-OH DPAT (3 mg/kg, i.p.) significantly suppressed LTP induction in the males. Synaptic responses to CFC and 5-HT1A receptor interventions were not observed in the females. These results suggest that the metaplastic 5-HTergic mechanism via 5-HT1A receptors in the MRN-hippocampus pathway is a key component for gender-specific emotional regulation and may be a cause of psychiatric disorders associated with vulnerability or resistance to emotional stress.

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (69)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ