Tandospirone Suppresses Impulsive Action by Possible Blockade of the 5-HT<sub>1A</sub> Receptor
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- Ohmura Yu
- Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Japan
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- Kumamoto Haruko
- Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Japan
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- Tsutsui-Kimura Iku
- Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Japan Research Fellow of the Japan Society for the Promotion of Science
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- Minami Masabumi
- Department of Pharmacology, Hokkaido University Graduate School of Pharmaceutical Sciences, Japan
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- Izumi Takeshi
- Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Japan
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- Yoshida Takayuki
- Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Japan
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- Yoshioka Mitsuhiro
- Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Japan
Bibliographic Information
- Other Title
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- Tandospirone Suppresses Impulsive Action by Possible Blockade of the 5-HT[1A] Receptor
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Abstract
Higher impulsivity is observed in several psychiatric disorders and could be a risk factor for drug addiction, criminal involvement, and suicide. Although the involvement of the 5-HT1A receptor in impulsive behavior has been indicated, the effects of clinically relevant drugs have been rarely tested. In the present study, we examined whether (3aR,4S,7R,7aS)-rel-hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione hydrochloride (tandospirone), an anxiolytic and a partial agonist of the 5-HT1A receptor, could affect impulsive action in the 3-choice serial reaction time task. Rats were acutely administered tandospirone (0, 0.1, and 1 mg/kg, i.p.). Tandospirone decreased the number of premature responses, an index of impulsive action, in a dose-dependent manner. N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate salt (WAY100635; 0.3 mg/kg, s.c.), a 5-HT1A receptor antagonist, did not reverse the suppressing effects of tandospirone on impulsive action. Moreover, a higher dose of WAY100635 (1 mg/kg, s.c.) suppressed impulsive action without tandospirone. Thus the effects of tandospirone on impulsivity might be due to the antagonistic action. Tandospirone could be a therapeutic candidate for impulsivity-related disorders.
Journal
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 122 (2), 84-92, 2013
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390282680157628928
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- NII Article ID
- 10031185400
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- NII Book ID
- AA11806667
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- COI
- 1:STN:280:DC%2BC3snmvVGisA%3D%3D
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- ISSN
- 13478648
- 13478613
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- NDL BIB ID
- 024637785
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- PubMed
- 23707971
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed