Baicalin From Scutellaria baicalensis Impairs Th1 Polarization Through Inhibition of Dendritic Cell Maturation
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- Kim Mi Eun
- Department of Biology, College of Natural Sciences, Chosun University, South Korea
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- Kim Hyung Keun
- Heart Research Center of Chonnam National University Hospital, Cardiovascular Research Institute, Chonnam National University, Korea
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- Park Hyeon-Young
- Department of Biology, College of Natural Sciences, Chosun University, South Korea
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- Kim Dae Hyun
- Molecular Inflammation Research Center for Aging Intervention (MRCA), Department of Pharmacy, Pusan National University, Korea
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- Chung Hae Young
- Molecular Inflammation Research Center for Aging Intervention (MRCA), Department of Pharmacy, Pusan National University, Korea
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- Lee Jun Sik
- Department of Biology, College of Natural Sciences, Chosun University, South Korea
書誌事項
- タイトル別名
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- Baicalin From <i>Scutellaria baicalensis</i> Impairs Th1 Polarization Through Inhibition of Dendritic Cell Maturation
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抄録
Baicalin from Scutellaria baicalensis is a major flavonoid constituent found in the traditional Chinese medicinal herb Baikal skull cap. It has been widely used for the treatment of various diseases such as pneumonia, diarrhea, and hepatitis. Recent studies have demonstrated that baicalin possesses a wide range of pharmacological and biological activities, including anti-inflammatory, anti-microbial, anti-oxidant, and anti-tumor properties. Specifically, its anti-inflammatory activity has been estimated in various animal models of acute and chronic inflammation; however, its effects on dendritic cells (DCs) maturation and immuno-stimulatory activities are still unknown. In this study, we attempted to determine whether baicalin could influence DC surface molecule expression, antigen uptake capacity, cytokine production, and capacity to induce T-cell differentiation. Baicalin was shown to significantly suppress the expression of surface molecules CD80, CD86, major histocompatibility complex (MHC) class I, and MHC class II as well as the levels of interleukin-12 production in lipopolysaccharide stimulated DCs. Moreover, baicalin-treated DCs showed an impaired induction of the T helper type 1 immune response and a normal cell-mediated immune response. These findings provide important understanding of the immunopharmacological functions of baicalin and have ramifications for the development of therapeutic adjuvants for the treatment of DCs-related acute and chronic diseases.
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 121 (2), 148-156, 2013
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282680157789056
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- NII論文ID
- 10031156944
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- NII書誌ID
- AA11806667
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- COI
- 1:CAS:528:DC%2BC3sXjvVyisr4%3D
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 024275113
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- PubMed
- 23419270
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可