MDR1 Haplotype Frequencies in Japanese and Caucasian, and in Japanese Patients with Colorectal Cancer and Esophageal Cancer

DOI Web Site Web Site PubMed 被引用文献7件 参考文献47件
  • KOMOTO Chiho
    Department of Hospital Pharmacy, Kobe University
  • NAKAMURA Tsutomu
    Department of Hospital Pharmacy, Kobe University
  • SAKAEDA Toshiyuki
    Department of Hospital Pharmacy, Kobe University Division of Clinical Pharmacokinetics, Department of General Therapeutics, Kobe University Graduate School of Medicine
  • KROETZ Deanna L.
    Department of Biopharmaceutical Science, University of California San Francisco Program in Human Genetics, University of California San Francisco
  • YAMADA Toshio
    Division of Clinical Pharmacokinetics, Department of General Therapeutics, Kobe University Graduate School of Medicine
  • OMATSU Hideaki
    Department of Hospital Pharmacy, Kobe University
  • KOYAMA Tatsuya
    Division of Clinical Pharmacokinetics, Department of General Therapeutics, Kobe University Graduate School of Medicine
  • OKAMURA Noboru
    Department of Clinical Evaluation of Pharmacotherapy, Graduate School of Medicine, Kobe University
  • MIKI Ikuya
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine
  • TAMURA Takao
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine
  • AOYAMA Nobuo
    Endoscopy, School of Medicine, Kobe University
  • KASUGA Masato
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine
  • OKUMURA Katsuhiko
    Department of Hospital Pharmacy, Kobe University Division of Clinical Pharmacokinetics, Department of General Therapeutics, Kobe University Graduate School of Medicine Department of Clinical Evaluation of Pharmacotherapy, Graduate School of Medicine, Kobe University

この論文をさがす

説明

   The genotype frequencies of MDR1 T-129C, C1236T, G2677A,T and C3435T SNPs were compared in 154 healthy Japanese and 100 healthy Caucasians to provide basic information on the inter-ethnic differences of pharmacotherapeutic outcome. The variants were found at allelic frequencies of 5.5%, 65.6%, 16.6%, 40.6% and 40.6%, for T-129C, C1236T, G2677A, G2677T and C3435T, respectively, in Japanese, and at 5.1%, 45.9%, 3.6%, 46.4% and 56.6%, respectively, in Caucasians, with a statistically significant difference for C1236T, G2677A,T and C3435T (p<0.001). G2677A was about 5-fold more frequent in Japanese than Caucasians. These genotype frequencies were also investigated in 95 Japanese patients with colorectal cancer (CRC) and esophageal squamous cell carcinoma (ESCC), but no significant difference was detected, when compared with healthy Japanese subjects. The haplotype frequency reached a total of about 85% in Japanese with the following 4 major haplotypes;<br>   T-129-T1236-T2677-T3435 (36.1%), T-129-T1236-G2677-C3435 (22.5%),<br>   T-129-C1236-G2677-C3435 (14.2%) and T-129-C1236-A2677-C3435 (13.3%). The second and fourth haplotypes were hardly inferred in Caucasian, whereas T-129-C1236-G2677-T3435 (12.8%) was found to be Caucasian-specific. There was a tendency for higher frequencies of the T-129/C-129-C1236-A2677-C3435 haplotype in Japanese CRC patients and T-129-T1236-T2677-T3435 haplotype in Japanese ESCC patients, compared with that in healthy Japanese subjects.<br>

収録刊行物

被引用文献 (7)*注記

もっと見る

参考文献 (47)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ