Impact of Systemic Histamine Deficiency on the Crosstalk Between Mammary Adenocarcinoma and T Cells
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- Hegyesi Hargita
- Department of Genetics, Cell and Immunobiology, Hungary
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- Colombo Lucas
- Immunobiology Department, Institute of Oncology Angel H. Roffo, Argentina
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- Pállinger Éva
- Department of Genetics, Cell and Immunobiology, Hungary
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- Tóth Sára
- Department of Genetics, Cell and Immunobiology, Hungary
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- Boer Katalin
- Department of Genetics, Cell and Immunobiology, Hungary
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- Molnár Viktor
- Department of Genetics, Cell and Immunobiology, Hungary
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- Falus András
- Department of Genetics, Cell and Immunobiology, Hungary
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The purpose of the present study was to investigate the influence of lack of histamine (HA) on tumor growth and functions of T cells in order further to illustrate the mechanism of immunological tolerance induction by HA. We assessed the phenotype and cytokine production of splenic lymphocytes in syngeneic HA-free (histidine decarboxylase knock-out) (HDC KO) and wild-type mice, inoculated subcutaneously with the LM2 murine breast cancer cell line. Relative quantification of target mRNA was performed with a TaqMan real-time RT-PCR assay. The CD4+CD25high+ Treg cell numbers were significantly smaller in the tumor-bearing KO mice than in the wild type ones measured by flow-cytometry. The expression of forkhead box P3 (Foxp3) decreased significantly and the copies of splenic Tbox-21 (T-bet) transcriptional factor mRNA was higher in HDC KO tumor-bearing mice than those of normal mice. The cytokine levels showed that a smaller number of interleukin-13-producing Th2 cells were elicited compared to interferon-γ-producing Th1 cells in the tumor-bearing HDC KO mice. In conclusion, the present study demonstrates that endogenous histamine stimulates the growth of breast adenocarcinoma tumor implants in mice by suppressing anti-tumor immunity.<br>
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 105 (1), 66-73, 2007
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282680158218368
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- NII論文ID
- 10024315741
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- NII書誌ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 8918816
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可