Protective Effects of Guizhi-Fuling-Capsules on Rat Brain Ischemia/Reperfusion Injury

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  • Li Tie-Jun
    Department of Pharmacology, School of Pharmacy, Second Military Medical University, China
  • Qiu Yan
    Department of Pharmacology, School of Pharmacy, Second Military Medical University, China
  • Mao Jun-Qin
    Department of Pharmacy, 85 Hospital, China
  • Yang Peng-Yuan
    Department of Pharmacology, School of Pharmacy, Second Military Medical University, China
  • Rui Yao-Cheng
    Department of Pharmacology, School of Pharmacy, Second Military Medical University, China
  • Chen Wan-Sheng
    Department of Pharmacy, Changzheng Hospital, China

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Previous studies revealed that Guizhi-Fuling-Capsules (GZFLC), a traditional Chinese medical (Kampo) formulation composed of five kinds of medicinal plants, Cinnamomum cassia B<sc>LUME</sc> (Cinnamomi Cortex), Paeonia lactiflora P<sc>ALL</sc>. (Peonies Radix), Paeonia suffruticosa A<sc>NDREWS</sc> (Moutan Cortex), Prunus persica B<sc>ATSCH</sc> (Persicae Semen), and Poria cocos W<sc>OLF</sc> (Hoelen), exerts a protective effect against vascular injury and has a protective effect against glutamate- or nitro oxide-mediated neuronal damage. In the present study, the effect of GZFLC in a rat in vivo model of focal cerebral ischemia and reperfusion was investigated. Administration of GZFLC (0.3 and 0.9 g/kg, p.o.) after focal cerebral ischemia significantly decreased brain infarction and water contents in rats subjected to 2-h ischemia followed by 24-h reperfusion from 31.72 ± 2.49%, 84.76 ± 1.63% in the model group to 17.31 ± 3.66%, 82.51 ± 1.36% and 8.30 ± 3.73%, 81.35 ± 1.73%, respectively. Furthermore, analysis of inflammatory cytokines in ischemic brain showed that GZFLC treatment significantly down-regulated expressions of pro-inflammatory cytokines including interleukin (IL)-1β and tissue necrosis factor-α and markedly up-regulated expressions of anti-inflammatory cytokines IL-10 and IL-10R both in mRNA and protein levels. The serum levels of these inflammatory cytokines were also regulated the same way. These results suggested that GZFLC may be beneficial for the treatment of brain ischemia-reperfusion injury partly due to its anti-inflammatory properties.<br>

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