Comparison of Biodistribution and Biocompatibility of Gelatin-Coated Copper Nanoparticles and Naked Copper Oxide Nanoparticles
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- Abe Shigeaki
- Graduate School of Dental Medicine, Hokkaido University, Japan
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- Iwadera Nobuki
- Graduate School of Dental Medicine, Hokkaido University, Japan
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- Narushima Takashi
- Division of Materials Science and Engineering, Faculty of Engineering, Hokkaido University, Japan
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- Uchida Yoshiki
- Division of Materials Science and Engineering, Faculty of Engineering, Hokkaido University, Japan
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- Uo Motohiro
- Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Japan
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- Akasaka Tsukasa
- Graduate School of Dental Medicine, Hokkaido University, Japan
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- Yawaka Yasutaka
- Graduate School of Dental Medicine, Hokkaido University, Japan
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- Watari Fumio
- Graduate School of Dental Medicine, Hokkaido University, Japan
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- Yonezawa Tetsu
- Division of Materials Science and Engineering, Faculty of Engineering, Hokkaido University, Japan
Bibliographic Information
- Published
- 2012
- Resource Type
- journal article
- DOI
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- 10.1380/ejssnt.2012.33
- Publisher
- The Japan Society of Vacuum and Surface Science
Description
In this study, we investigated the biocompatibility of gelatin-coated copper nanoparticles. To estimate their cytotoxicity, the coated copper nanoparticles were exposed to osteoblastic cells. The cell proliferation remained above 80% even when the particles concentration increased. When uncoated copper oxide nanoparticles were exposed to the cells, the proliferation ratio rapidly decreased with the concentration reaching 20% under the same conditions. To determine their biodistribution, the nanoparticles were administered to mice through their tail veins. The particles were subsequently found in some organs using an energy-dispersed X-ray spectrometer and inductively coupled plasma-atomic emission spectroscopy. The polymer-coated nanoparticles were observed in the lung, liver and spleen. They were also detected in the urine at higher concentrations than the copper oxide nanoparticles. Thus, the polymer coating is expected to improve biocompatibility by virtue of the excellent cytocompatibility and acceleration of the excretion process. [DOI: 10.1380/ejssnt.2012.33]
Journal
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- e-Journal of Surface Science and Nanotechnology
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e-Journal of Surface Science and Nanotechnology 10 (0), 33-37, 2012
The Japan Society of Vacuum and Surface Science
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Details 詳細情報について
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- CRID
- 1390282680164331392
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- NII Article ID
- 130004438789
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- ISSN
- 13480391
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
- OpenAIRE
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- Abstract License Flag
- Disallowed