A Case of Giant Squamous Cell Carcinoma Arising from the Burn Scar with Lung Metastasis

DOI
  • NAGATA Naoko
    Department of Dermatology, Osaka University Graduate School of Medicine
  • TANEMURA Atsushi
    Department of Dermatology, Osaka University Graduate School of Medicine
  • TANAKA Kaoru
    Department of Dermatology, Osaka University Graduate School of Medicine
  • YAJIMA Tomoko
    Department of Dermatology, Osaka University Graduate School of Medicine
  • TANI Mamori
    Department of Dermatology, Osaka University Graduate School of Medicine
  • KATAYAMA Ichiro
    Department of Dermatology, Osaka University Graduate School of Medicine
  • TAMAI Noriyuki
    Department of Orthopedics, Osaka University Graduate School of Medicine
  • SAWABATA Akiyoshi
    Department of Thoracic surgery, Osaka University Graduate School of Medicine

Bibliographic Information

Other Title
  • 初診時に肺転移を生じていた下腿巨大熱傷瘢痕癌の1例
  • ―当科でこれまで経験した瘢痕癌との臨床的比較検討―
  • ―Comparison to 7 Cases Experienced in Our Department―

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Abstract

A 58-year-old man had suffered a burn injury from the left lower leg to patella from briquette coal at 2 years old. Because a small ulcerative nodule on his left patella had grown rapidly for 5 months before visiting our hospital, the patient was referred to our department with a suspicion of squamous cell carcinoma of the skin arising from the burn scar. The mass reached 20×20cm in diameter and its surface was cauliflower-shaped with profuse exudates. The patient underwent amputation of the left leg above knee level and radical left inguinal lymph node dissection with staging of pT3N1M0 stage III according to UICC 2002. The tumor cells were moderately differentiated and we did not find direct invasion of lymph or blood vessels. Six weeks after surgery, sequential chest CT detected an increase consolidation on the right lung, suggesting lung metastasis. The combination of radical pneumectomy and sequential chemotherapy was temporarily effective to control metastatic lesions on the lung. Given the early detection of lung metastasis after the 1st operation, we suspected that metastasis to the lung had already occurred at the time of initial whole body screening. In this report, we compare the clinical characteristics between this case and 7 cases experienced in our department. In 4 cases, the tumor was over 10cm and we suppose that the size of the tumor is related to the prognosis. Moreover, recurrence, metastasis to lymph nodes, and distant metastasis were each detected in 1 case (12.5%), 3 cases (37.5%), and 2 cases (25%), respectively, and the prognosis of squamous cell carcinoma arising from a burn scar is considered to be worse than that of squamous cell carcinoma without a scar.Skin Research, 10: 298-304, 2011

Journal

  • Hifu no kagaku

    Hifu no kagaku 10 (4), 298-304, 2011

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

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