A Survey on the Efficacy of a 0.05% Difluprednate Ophthalmic Emulsion and a 0.1% Betamethasone-compounded Ophthalmic Solution in Canine Anterior Uveitis

DOI

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Other Title
  • 犬の前部ぶどう膜炎における0.05% ジフルプレドナート乳濁点眼液と0.1%ベタメタゾン配合点眼薬の有効性に関する調査

Abstract

The efficacy of anti-inflammatory action of difluprednate (DFBA), a difluorinated derivative of prednisolone, was compared with betamethasone (BM), which is used conventionally in veterinary medicine. The survey was conducted between a 0.05% DFBA ophthalmic emulsion and a 0.1% BM ophthalmic solution using 51 dogs with anterior uveitis. There were no significant difference in the efficacy rates between DFBA (86.2%, 25/29) and BM (86.4%, 19/22). Clinical symptoms such as lacrimation, photophobia, blepharospam and discharge of eye mucus were improved after 2-week administration in both groups. A cloudy appearance of the anterior chamber and ciliary flush, both of which are characteristic signs of anterior uveitis, were also improved in both groups. DFBA was efficient against iris swelling, miosis, and iris color change, but BM was not. Elevation of intraocular pressure was found in the BM Group, but not in the DFBA Group. DFBA has been reported to have higher permeability in the iris than BM, and our observation confirmed this. No side effects were seen in either eye drops. In conclusion, DFBA has a therapeutic effect comparable to BM in dogs with anterior uveitis.

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Details 詳細情報について

  • CRID
    1390282680165827328
  • NII Article ID
    130004493418
  • DOI
    10.11252/dobutsurinshoigaku.21.103
  • ISSN
    18811574
    13446991
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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