A Case of Erythema Exsudativum Mutiforme-Type Drug Eruption due to Clindamycine (Daracin<SUP>®</SUP>), which was triggered by HHV-6 infection

DOI
  • Ueno Kengo
    Department of Dermatology, Kinki University School of Medicine
  • Aragane Yoshinori
    Department of Dermatology, Kinki University School of Medicine
  • Asai Mutsuyo
    Department of Dermatology, Kinki University School of Medicine
  • Kawada Akira
    Department of Dermatology, Kinki University School of Medicine
  • Tezuka Tadashi
    Department of Dermatology, Kinki University School of Medicine

Bibliographic Information

Other Title
  • HHV-6に誘発されたクリンダマイシン(ダラシン<SUP>®</SUP>)による多型滲出性紅斑型薬疹の1例

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Description

Here, we report a case of erythema exsudativum multiforme (EEM)-type drug eruption. A 38 year-old patient was treated with intravenous drip infusion of clindamicine and oral intake of minocycline chloride. Together with fever up to 39°C and mild liver involvement, EEM-like lesions appeared on the lower extremities and subsequently expanded to the whole body. Upon hospitalization to our university clinic, clindamycine and minocycline was interrupted under the suspicion of drug eruption. Fosfomycin was then, administered. Oral administration of 30mg prednisolon resulted in rapid resolution of symptoms, including skin rashes, fever and liver dysfunction. The specific IgM and IgG antibody titers of human herpesvirus type 6 (HHV-6) were elevated. The patch testing revealed positive reactions with various concentrations of clindamycine (10%, 1%, 0.1%) but not with other drugs. Finally, she was diagnosed having a drug eruption (EEM-type) due to clindamycine.

Journal

  • Hifu no kagaku

    Hifu no kagaku 3 (5), 466-470, 2004

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

Keywords

Details 詳細情報について

  • CRID
    1390282680166028672
  • NII Article ID
    130005436712
  • DOI
    10.11340/skinresearch.3.5_466
  • ISSN
    18839614
    13471813
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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