Pulmonary Squamous Cell Carcinoma in a Dog

DOI 13 References
  • UMEHARA Ai
    Department of Veterinary Pathology, College of Bioresource Sciences, Nihon University
  • SATO Tsuneo
    Department of Veterinary Pathology, College of Bioresource Sciences, Nihon University
  • SHIBUYA Hisashi
    Department of Veterinary Pathology, College of Bioresource Sciences, Nihon University
  • SUZUKI Kazuhiko
    Department of Veterinary Pathology, College of Bioresource Sciences, Nihon University
  • KOIE Hiroshi
    Laboratory of Comprehensive Veterinary Clinical Studies, College of Bioresource Sciences, Nihon University
  • SEKI Mamiko
    Laboratory of Comprehensive Veterinary Clinical Studies, College of Bioresource Sciences, Nihon University
  • YAMAUCHI Rie
    Laboratory of Comprehensive Veterinary Clinical Studies, College of Bioresource Sciences, Nihon University

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  • 犬の肺に発生した扁平上皮癌の1例

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A ten-year-old male beagle was referred to our hospital with complaints of severe coughing and multiple ventricular extrasystole. The dog was given supportive medication, but died 18 days after the first visit to us. Autopsy revealed a huge primary lung tumor, which was histologically diagnosed as a moderately differentiated squamous cell carcinoma with formation of cancer nodules. The neoplasms showed alveolar structure of neoplastic spinous cells with atypical nuclei, numerous mitoses, and single cell keratinizatio Immunohistochemically, the neoplastic cells reacted strongly to cytokeratin antibody, and most of the cytoplasm reacted to p53 protein antibody. Electron microscopy revealed a small number of tonofilaments within the neoplastic cells, and a large number of desmosomes among the neoplastic cells. This is the first report of the presence of p53 protein in cytoplasm in canine pulmonary squamous cell carcinoma.

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