A Case of Lymphomatoid Papulosis Followed by Primary Cutaneous Anaplastic Large Cell Lymphoma with Subsequent Lymph Node and Bone Involvement

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  • リンパ腫様丘疹症として経過観察中にリンパ節と骨病変を伴う原発性皮膚未分化大細胞リンパ腫へ進展した1例

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A 64-year-old woman had been suffering from a ten-month history of erythemas and papules with waxing and waning on the face, lateral thoracic regions and upper arms. A biopsy specimen revealed infiltration of atypical lymphocytes in the dermis, which were positive for CD30 and CLA, and negative for ALK and EMA. No findings observed on physical and radiologic examination or blood tests suggested extracutaneous disease. Thus, we diagnosed her with lymphomatoid papulosis (LyP). After a year, some lesions on the face persisted without spontaneous regression. Oral methotrexate was applied for 7 months, resulting in poor response. Two months later, these lesions showed self-healing. Four months later, papules relapsed and rapidly worsened to enlarge on lateral thoracic regions and lower extremities, and lymphadenopathy and left iliac neoplasm developed. Biopsy specimens of both skin and bone revealed infiltration of atypical lymphocytes, which were positive for CD30 and CLA, and negative for ALK and EMA. We therefore diagnosed her with primary cutaneous anaplastic large cell lymphoma with subsequent lymph node and bone involvement.Skin Research, 13: 1-7, 2014

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  • Hifu no kagaku

    Hifu no kagaku 13 (1), 1-7, 2014

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

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