A Case of Atopic Dermatitis with Concomitant Sjögren's Syndrome and Primary Biliary Cirrhosis

DOI
  • TSUCHIYAMA Shinji
    Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine
  • WASHIO Ken
    Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine
  • TAKASAGO Emi
    Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine
  • MASAKI Taro
    Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine
  • FUKUNAGA Atsushi
    Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine
  • OGAWA Satoshi
    Department of Dermatology, Hyogo Prefectural Awaji Medical Center
  • SAITO Masaya
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine
  • YANO Yoshihiko
    Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine
  • NISHIGORI Chikako
    Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine

Bibliographic Information

Other Title
  • アトピー性皮膚炎の加療中にシェーグレン症候群と原発性胆汁性肝硬変を発見した1例

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Abstract

A 44-year-old female was referred to our dermatology department with generalized eczema. She had been diagnosed with atopic dermatitis in childhood and was treated with corticosteroid ointments, but she had refused to use them for 10 years. As her eczema exhibited seasonal exacerbation, we performed a heat-loading sweat test, which revealed severe hypohidrosis her patient's face and trunk. As she had many tooth caries, we suspected that she had Sjögren's syndrome. A blood test produced positive results for anti-SS-A and anti-SS-B antibodies, and a lip biopsy showed numerous infiltrates of mononuclear cells around the minor salivary gland ducts. We administered topical therapy for atopic dermatitis, which resulted in the patient's hepatic enzyme levels rising. As she had Sjögren's syndrome, we searched for other autoimmune diseases, which led to her being diagnosed with primary biliary cirrhosis. Although hypohidrosis is a common manifestation of atopic dermatitis, clinicians should consider the possibility that it might be a complication of Sjögren's syndrome in severe cases. We also discuss the Th1/Th2/Th17 balance in relation to hepatic dysfunction during the treatment of atopic dermatitis.Skin Research, 15: 51-56, 2016

Journal

  • Hifu no kagaku

    Hifu no kagaku 15 (2), 51-56, 2016

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

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