Three Cases of Immediate Hypersensitivity to Quinolones: Analysis of Cross-reactivity between Quinolones

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  • ニューキノロン系抗菌剤による即時型アレルギーの3例
  • ―交差反応についての検討―

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Description

We report three cases of immediate hypersensitivity to quinolones. We divided quinolones into two groups: those consisting of a bicyclic or a tricyclic ring structure. The sensitizing and cross-reactivity drugs were as follows: ciprofloxacin and moxifloxacin with a bicyclic ring structure (Case 1), levofloxacin and pazufloxacin with a tricyclic ring structure (Case 2), and levofloxacin and ofloxacin containing its optical isomer (Case 3). It is likely that antigenic determinants are a cyclopropyl group in position 1 of a bicyclic ring structure and a pyridobenzoxazine ring of a tricyclic ring structure. Our data indicate that cross-reactivity of quinolones tends to occur within groups and may not occur between different groups.Skin Research, 13: 278-284, 2014

Journal

  • Hifu no kagaku

    Hifu no kagaku 13 (4), 278-284, 2014

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

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