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- TAKIZAWA Aiko
- 東北大学病院顎口腔機能治療部
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- OTA Takeru
- 東北大学大学院歯学研究科
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- YASUDA Mayumi
- 東北大学大学院歯学研究科
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- HAYASHI Haruhide
- 東北大学大学院歯学研究科
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- SHINODA Hisashi
- 東北大学大学院歯学研究科
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- CHIBA Mirei
- 東北大学大学院歯学研究科
Bibliographic Information
- Other Title
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- 卵巣摘出ラット脛骨のマイクロCT解析
- ランソウ テキシュツ ラットケイコツ ノ マイクロ CT カイセキ
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Abstract
Postmenopausal osteoporosis results from an increase in activation frequency and an imbalance between bone formation and resorption. Osteoporosis is a skeletal disorder characterized by compromised bone strength that predisposes an individual to an increased risk of fracture. We investigated the bones of rats with osteoporosis induced by ovariectomy. Female Sprague-Dawley rats (12 weeks old) were subjected to ovariectomy or a sham-ovariectomy operation. Images of tibial metaphysis were obtained using a micro-computed tomography (micro-CT) scanner, and were subjected to subsequent analyses. Three-dimensional (3D) data were obtained by constructing sliced images along the bone axis and evaluated using an image analyzer. Histological assessment was performed to confirm the bone structure and pathological observation of the obtained image. The micro-CT results of parameter analysis showed decreased bone mass and deterioration in the structural properties critical to the mechanical strength of osteoporotic bone. In conclusion, 3D-CT imaging provides an accurate noninvasive method for directly measuring bone architecture. Micro-CT imaging of small animals allows the evaluation of bone morphology and micro-architecture in animal models, such as bone loss induced by estrogen deficiency.
Journal
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- Journal of the Japanese Society for Experimental Mechanics
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Journal of the Japanese Society for Experimental Mechanics 16 (2), 140-146, 2016
The Japanese Society for Experimental Mechanics
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Keywords
Details 詳細情報について
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- CRID
- 1390282680167542272
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- NII Article ID
- 130005165140
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- NII Book ID
- AA11822914
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- ISSN
- 18844219
- 13464930
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- NDL BIB ID
- 027556325
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed