Genetic variation of response to Testosterone on sexual accessory glands of mice

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  • KOBAYASHI Kayo
    Laboratory of Animal Breeding, Department of AnimalHusbandry, Faculty of Agriculture, Tohoku University
  • MIZUMA Yutaka
    Laboratory of Animal Breeding, Department of AnimalHusbandry, Faculty of Agriculture, Tohoku University
  • NISHIDA Shusaku
    Laboratory of Animal Breeding, Department of AnimalHusbandry, Faculty of Agriculture, Tohoku University

Bibliographic Information

Other Title
  • テストステロンに対するマウス精のう•前立腺反応の遺伝的変異に関する研究
  • テストステロン ニ タイスル マウスセイノウ ゼンリツセン ハンノウ ノ イデンテキ ヘンイ ニ カンスル ケンキュウ 1 ヨウジャク マウス ニ オケル ジュウリョウ ハンノウ ノ ケイトウサ ト ソノ イデン
  • I. Strain differences in immature mice of inbred strains and their F1 and F2
  • I. 幼若マウスにおける重量反応の系統差とその遺伝

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An experiment was conducted to determine the growth response of the seminal vesicle and prostate to Testosterone Propionate (T. P. ) in several inbred strains of the mouse, SS, RR, CFW, C57BL/6, and their F1 and F2 hybrids, SS_??_×RR_??_(SR), RR_??_×SS_??_(RS), SR×SR and RS×RS.<br>Various doses of T. P. (total dose of T. P.: 0.01, 0.05, 0.25, 1.25 and 6.25mg) were administered intraperitoneally to immature animals from 16 to 20 days of age.<br>All treated mice were weighed and autopsied on the day following the last injection, then the organs were removed and weighed.<br>Heritability estimate of the response to 1.25mg T. P. was calculated from analysis of variance for randombred mice (RB) derived from the base population which consisted of the crossbred of four inbred lines.<br>The results are summarized as follows:<br>(1) In SS strain seminal vesicles and prostates responded significantly greater than those in other inbred strains: RR, C57BL/6 and CFW, especially to the high T. P. doses.<br>(2) The response to T. P. in F1 mice (SR and RS) was demonstrated to be intermediate between that of their parents, and the response of F2 was not significantly different from F1. However, F1 mice showed heigher response to the lower T. P. concentration than their parental strains.<br>(3) Heritability estimates of the response in the randombred population were h2 S=0.21±0.62, h2 D=2.56±0.94 and h2 S+D=1.38±0.16.<br>(4) Coefficient of variation of the response to T. P. in F1 mice was smaller than that of inbred strains and F2 offsprings.

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