Clinical Experience of the Treatment by Oral Administration of Doxycycline and Ivermectin Combined with a Single Injection of Melarsomine for Canine Heartworm Disease

DOI

Bibliographic Information

Other Title
  • ドキシサイクリンおよびイベルメクチンの経口投与およびメラルソミン1回注射併用による犬のフィラリア症の治療経験

Search this article

Description

<p>Twenty-two dogs diagnosed with canine heartworm disease (HWD) were classified into four groups (Class 1 [11 dogs], Class 2 [5 dogs], Class 3 [5 dogs], and Class 4 [1 dog]). Treatment was attempted with oral doxycycline and ivermectin combined with a single injection of melarsomine. The mean survival time until the final observation day was 504 days [22 dogs], and the mortality was 22.7% ([5/22 dogs]: Class 1 [1/11 dogs], Class 3 [4/5 dogs]). The mean time to negative conversion on the antigen test before the final observation day was 312 days, and the negative conversion rate was 95% (19 of the 20 dogs tested were negative) . Furthermore, in Class 3 dogs, the ascites disappeared for 76 days in 1 dog and for 685 days in another dog, and the disappearance of ascites and significant improvement in fainting spells were observed for 812 days in 1 dog. Moreover, improvement in the findings of the chest X-ray examination and significant improvement in the clinical symptoms were confirmed in 1 dog in Class 4. Our results indicate that treatment with oral doxycycline and ivermectin combined with a single injection of melarsomine is safe and can be effectively used for the treatment of canine HWD.</p>

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top