ヒツジの血糖維持に対するグルココルチコイドの役割

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タイトル別名
  • The Role of Glucocorticoids for the Maintenance of Plasma Glucose Levels in Sheep
  • ヒツジ ノ ケットウ イジ ニ タイスル グルココルチコイド ノ ヤクワリ エ

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抄録

The role of adrenocortical hormones for the maintenance of plasma glucose levels in ruminants was evaluated in adrenalectomized (ADX) sheep under both fed and fasted conditions. Plasma glucose levels were compared between ADX sheep with glucocorticoid therapy (GC-treated ADX group) and without therapy (untreated ADX group) at fed state in Expt. 1, and between these ADX groups and intact sheep (intact group) at fasted state in Expt. 2. The therapeutic effectiveness of glucocorticoids on hypoglycemic ADX sheep was examined at fasted state in Expt. 3. At the fed state, untreated ADX group maintained plasma glucose levels at 90% of those observed in GC-treated ADX group in Expt. 1 (P<0.001). In contrast, plasma glucose levels of untreated ADX group were lowered to less than 60% of the pre-fasting levels at the 3 rd day of fasting. In GC-treated ADX group, plasma glucose levels remained at the highest of all groups until 15 days of fasting. The intact and GC-treated ADX sheep in Expt. 2 did not show any hypoglycemic sign during the fasted period, but all of untreated ADX sheep showed clear hypoglycemic signs. When glucocorticoid was administrated to the hypoglycemic sheep, the levels of plasma glucose increased and recovery from hypoglycemia was observed in Expt. 3. From these results, it was concluded that glucocorticoids were essential for the maintenance of plasma glucose levels under fasted conditions in ruminants, but not at fed state.

収録刊行物

  • 日本畜産学会報

    日本畜産学会報 58 (11), 969-977, 1987

    公益社団法人 日本畜産学会

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