Studies on Myoglobinuria caused in Horses Following Exercise I

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  • MATSUMOTO Kyuki
    Laboratory of Animal Breeding, Faculty of Agriculture, Hokkaido University
  • OKADA Ikuo
    Laboratory of Animal Breeding, Faculty of Agriculture, Hokkaido University

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  • 馬の運動ミオグロビン尿に関する研究I
  • ウマ ノ ウンドウ ミオグロビン ニョウ ニ カンスル ケンキュウ 1

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The vicissitude of myoglobin and hemoglobin in the urine following strenuous exercise was studied experimentally. Also possible sources of myoglobinuria and hemoglobinuria was discussed.<BR>Methods: Mares were divided into three groups, A, B, and C, of three. The exercise was 12 kilometers' mounted gallop in group A, and 10 kilometers mounted and unmounted gallop in groups B and C, respectively, which was imposed every day for 3 to 5 days. Myoglobin and hemoglobin contents in urine and blood specimens collected before and after the exercise were determined serologically by the precipitin ring test. The antisera used were specific as shown in Table 1.<BR>The atmospheric condition during the experimental period was almost good and out-door temperature was 18 to 25°C (see Table 2).<BR>Results: 1) Some symptoms observed on the mares of each group before and after the exercise showed the same tendency. It took 3 hours until the physical condition of the mare returned to the normal state after the exercise (Tables 3 and 8).<BR>2) Hemoglobinemia was observed only in group A and not in the other groups. Myoglobinemia occurred in only one mare of group A. Both changes in the blood were observed at the end of the exercise (Tables 6 and 12).<BR>The mechanism of hemoglobinemia and myoglobinemia caused following the exercise was obscure.3) Myoglobinuria and hemoglobinuria were observed in the same mare of group A as described in the preceding paragraph (Table 5). Myoglobin in urine specimens decreased day by day, but hemoglobin had the opposite tendency.<BR>Different from myoglobinemia and hemoglobinemia, myoglobin and hemoglobin in the urine were observed for the first time 1 hour after the exercise.Hemoglobinuria was observed, however, only at 1 hour after the exercise. This discrepancy between myoglobin and hemoglobin is probably due to the difference in the renal threshold.<BR>4) Myoglobinuria and hemoglobinuria seemed to occur as a result of myoglobinemia and hemoglobinemia. They dissppeared a few hours after the exercise.<BR>5) Tests on sera for the production of autoantibody to myoglobin were negative (Table 7).<BR>6) In all mares of group A, except one mentioned in paragraphs 2 and 3, an unknown substance which reacted to various normal sera was found in urine speimens collected 1 hour after the exercise. The substance was not identified in this study.

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