Development of Secretory IgA Production in the Salivary Glands of Calves

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  • 子牛の唾液腺におけるIgA産生能の発達
  • コウシ ノ ダエキセン ニ オケル IgA サンセイノウ ノ ハッタツ

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Abstract

This experiment was carried out to examine the developmental change in IgA secretory function in the salivary glands with the aging of calves. The concentration of Igs in the serum, saliva and salivary glands collected from calves up to 52 weeks of age were measured. The population and types of plasma cells in the salivary glands were also investigated using immunohistochemical procedure. There was a continuous increase in IgA concentration with age in the mixed saliva and submaxillary glands as early as 4 weeks of age, whereas no obvious increases were observed in the serum or parotid glands. Mean IgA concentration in the submaxillary glands at 52 weeks of age was 14.9±6.2mg/g of dry tissue, comprising 70% or more of the total Igs. On the other hand, a large number of plasma cells was detected in the submaxillary glands at 4 weeks of age, after which those populations increased continuously until 52 weeks of age, whereas plasma cells in the parotid glands were almost completely absent at all weeks of age. Immunohistochemical study showed that the major cell type was an IgA producing cell infiltrated in the submaxillary glands with the aging of calves.

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