Correlation between Morphologic Changes and Autism Spectrum Tendency in Obsessive-Compulsive Disorder
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- KOBAYASHI Tomoko
- United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui Research Center for Child Mental Development, Chiba University
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- HIRANO Yoshiyuki
- United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui Research Center for Child Mental Development, Chiba University
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- NEMOTO Kiyotaka
- Department of Psychiatry, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba
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- SUTOH Chihiro
- Research Center for Child Mental Development, Chiba University
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- ISHIKAWA Kazuhiro
- Ibaraki Prefectural Medical Center of Psychiatry
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- MIYATA Haruko
- Research Center for Child Mental Development, Chiba University
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- MATSUMOTO Junko
- United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui Research Center for Child Mental Development, Chiba University Department of Regional Disaster Medicine, Graduate School of Medicine, Chiba University
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- MATSUMOTO Koji
- Department of Radiology, Chiba University Hospital
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- MASUDA Yoshitada
- Department of Radiology, Chiba University Hospital
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- NAKAZATO Michiko
- United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui Research Center for Child Mental Development, Chiba University
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- SHIMIZU Eiji
- United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui Research Center for Child Mental Development, Chiba University
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- NAKAGAWA Akiko
- United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui Research Center for Child Mental Development, Chiba University
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説明
Objectives: Obsessive-compulsive disorder (OCD) is one of the most debilitating psychiatric disorders, with some speculating that a reason for difficulty in its treatment might be its coexistence with autism spectrum. We investigated the tendency for autistic spectrum disorders (ASD) in patients with OCD from a neuroimaging point of view using voxel-based morphometry.<br/>Methods: We acquired T1-weighted images from 20 patients with OCD and 30 healthy controls and investigated the difference in regional volume between the groups as well as the correlation between Autism-Spectrum Quotient (AQ) scores and regional cerebral volumes of patients with OCD.<br/>Results: Volumes in the bilateral middle frontal gyri were significantly decreased in patients with OCD compared to controls. Correlational analysis showed significant positive correlations between AQ scores and regional gray matter (GM) volumes in the left dorsolateral prefrontal cortex (DLPFC) and left amygdala. Furthermore, GM volumes of these regions were positively correlated with each other.<br/>Conclusions: The positive correlation of ASD traits in patients with OCD with regional GM volumes in the left DLPFC and amygdala could reflect the heterogeneity of patient symptoms. Our results suggest that differences in GM volume might allow classification of patients with OCD for appropriate therapy based on their particular traits.
収録刊行物
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- Magnetic Resonance in Medical Sciences
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Magnetic Resonance in Medical Sciences 14 (4), 329-335, 2015
日本磁気共鳴医学会