イオノフォアの十二指腸内投与が去勢牛の代謝に及ぼす影響

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  • Effects of the Administration of Ionophores into the Duodenum on Metabolism of Steers
  • イオノフォア ノ ジュウニシチョウナイ トウヨ ガ キョセイ ウシ ノ タイシ

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Four Holstein steers weighing about 250kg and fitted with a duodenal cannula were used in two experiments to examine the effects of administration of sodium salts of monensin (MN), salinomycin (SL) and lasalocid (LA) into the duodenum on metabolism independent of the rumen fermentation. Twenty miligrams of each ionophore in Expt 1 and 50mg each in Expt 2 were dissolved in 2 and 3ml ethanol, respectively, and injected into the duodenum at 9:30, i.e. 1h after the morning feeding. In each case, four animals were assigned to four treatments including the injection of vehicle (2 or 3ml ethanol) as a control in a 4×4 Latin square design on every other day. Jugular blood were taken from -15 to 240min after the injection, and the concetrations of glucose, non-esterified fatty acids (NEFA) and minerals (Na, K, Mg, Ca and inorganic P) were measured. Although any ionophore did not affect these concentrations at the dose of 20mg, the administration of 50mg MN decreased significantly the serum NEFA concentration without a significant effect on the concentrations of plasma glucose and minerals. The administration of 50mg LA also tended to decrease the serum NEFA, whereas the administration of 50mg SL did not affect not only the plasma concentrations of glucose and minerals but also the serum NEFA concentration.

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