Effect of GABA-transaminase Inhibitor, Ethanolamine-O-sulphate, on Muscimol-induced Eating in Rats Kept at High and Temperate

KUROSE Yohei, YANO Hideo, MIYAZAKI Akira

doi:10.2508/chikusan.64.228

The present study was conducted to examine the effects of the transaminase inhibitor, ethanolamine-O-sulphate (EOS), on eating stimulated by the gammaaminobutyric acid (GABA) agonist, muscimol, in rats acclinated to temerate (26°C) and hot (33°C) environments. In addition, the effect of the GABA antagonist, bicuculline, on eating in rats acclimated to both environments was examined. Eating was stimulated by intraventricular injections of muscimol and bicuculline in freely-fed rats. The food intake in rats acclimated to the hot environment was less than that in rats acclimated to the temperate environment, when muscimol or bicuculline were given. The food intake in rats given both EOS and muscimol was greater than that in rats given muscimol alone at the temperate temperature. The food intake in rats acclimated to the hot environment was less than that in rats acclimated to the temperate environment, even after treatment with both EOS and muscimol. These results suggest that the difference in food intake, which increased via muscimol in rats acclimated to the two environments, might not be due to the change in the activity of transaminase. The possibility also exists that neurons, which are not affected by the modulation of GABA neurons, are correlated to the control of food intake in response to the change in environmental temperature.

Effect of GABA-transaminase Inhibitor, Ethanolamine-O-sulphate, on Muscimol-induced Eating in Rats Kept at High and Temperate

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