Mitogenic Activity of Cell Wall Components from <i>Lactobacillus acidophilus</i>

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  • Lactobacillus acidophilus細胞壁成分のリンパ球幼若化作用
  • Lactobacillus acidophilus サイボウヘキ セイブン ノ

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Abstract

In order to evaluate biological activities in Lactobacillus acidophilus, the mitogenic activity of the whole cell and hydrolyzed cell wall component (CWC) from 9 L. acidophilus strains were measured using murine spleen cells. Higher activity was generally observed in CWC than ih the whole cell, and was especially high in CWC from JCM strain 2125 (Stimulation Index=3.02 at 100μg/ml). CWC from JCM 2125 was fractionated via DEAE-ion exchange chromatography, followed by activity measurement and chemical analysis. The activity was mainly found in the fractions bound on the DEAE-column, and it was confirmed to be specific to the B-cell of murine spleen cells. Carbohydrate moiety of the active fractions was composed of glucose, Nacetylglucosamine, N-acetyl muramic acid and glycerol. Active fractions contained higher N-acetylglucosamine in their ratio to glucose.

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