1-Year Oral Toxicity Study of Chinese bayberry extract in F344/DuCrj Rats

DOI Web Site 7 References
  • Yoshino Hiroko
    Daiyu-kai Institute of Medical Science First Department of Pathology, Nagoya City University Medical School
  • Kawabe Mayumi
    Daiyu-kai Institute of Medical Science First Department of Pathology, Nagoya City University Medical School
  • Tamano Seiko
    Daiyu-kai Institute of Medical Science First Department of Pathology, Nagoya City University Medical School
  • Hagiwara Akihiro
    Daiyu-kai Institute of Medical Science First Department of Pathology, Nagoya City University Medical School
  • Washino Tsutomu
    San-Ei Gen F.F.I., Inc.
  • Nakamura Mikio
    San-Ei Gen F.F.I., Inc.
  • Imaida Katsumi
    First Department of Pathology, Nagoya City University Medical School

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Other Title
  • ヤマモモ抽出物の1年間反復投与毒性試験
  • ヤマモモ チュウシュツブツ ノ 1ネンカン ハンプク トウヨ ドクセイ シケン

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The present report concerns results of a 1-year oral toxicity study of Chinese bayberry extract, one active component of which is myricitrin, a flavonoid. F344 rats (20rats/group both sexes) were given diet containing Chinese bayberry extract at doses of 0, 0.5, 1.5 or 5.0%. Decrease in monocytes on differential counts of WBCs and increase of reticulocytes were observed in the 1.5 and 5.0% male groups. Significant decrease in relative lung weights was apparent in the 0.5, 1.5 and 5.0% males. However, these changes were considered incidental effects. No treatment related effects were noted regarding clinical observation, body weights, food and water consumption, ophthalmologic findings, clinical chemistry and pathology. In conclusion, 1 year dietary treatment with Chinese bayberry extract at levels up to 5.0% demonstrated no toxicologically significant effects in either male or female rats. It was thus inferred that the no-observed adverse effect level (NOAEL) was up to 5.0% in both sexes.

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