Growth suppression of rat hepatoma cells by a pentapeptide from Antheraea yamamai

DOI Web Site 被引用文献8件 参考文献21件
  • Yang Ping
    Department of Agro-Bioscience, Faculty of Agriculture, Iwate University
  • Abe Shizuko
    Department of Agro-Bioscience, Faculty of Agriculture, Iwate University
  • Zhao Yun-peng
    Cryobiosystem Research Center, Faculty of Agriculture, Iwate University
  • An Ying
    Department of Agro-Bioscience, Faculty of Agriculture, Iwate University
  • Suzuki Koichi
    Department of Agro-Bioscience, Faculty of Agriculture, Iwate University

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  • Growth Suppression of Rat Hepatoma Cells by a Pentapeptide from <i>Antheraea yamamai</i>

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説明

Asp-Ile-Leu-Arg-Gly-NH2 (DILRG-NH 2), a pentapeptide with amidated C-terminus, has been isolated from diapausing pharate first instar larvae of the wild silkmoth Antheraea yamamai. In this study, we examined effects of this peptide and three related compounds on the proliferation of rat hepatoma cells and mouse spleen lymphocytes. The amidated pentapeptide and its truncated version ILRG-NH2, not LRG-NH2 and the non-amidated pentapeptide, suppress proliferation of the rat hepatoma cells. This suppression may be due to a cell cycle arrest rather than to an apoptotic/necrotic activity. Amino acid residues 2-5 and carbonyl amidation appear essential for its activity. The results indicate that the isolated pentapeptide is a candidate for therapeutic use.<br>

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