Survey of current trends in the abuse of psychotropic plants using LC-MS

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  • 植物系違法ドラッグ製品のLC-MS分析による流通実態調査
  • ショクブツケイ イホウ ドラッグ セイヒン ノ LC MS ブンセキ ニ ヨル リュウツウ ジッタイ チョウサ

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In recent years, various products of non-controlled psychotropic plants have become popular in place of chemical psychotropic substances, which are now subject to stricter controls, and they are causing concern in Japan. To survey current trends in the abuse of psychotropic plants, 127 kinds of plant products (which were distributed from April 2004 to May 2007 in Japan) were analyzed using LC-ESI-MS. As a results of the analyses, 6 typical psychotropic plant components, N,N-dimethyltryptamine (DMT) (1.2% contents in the sample), mescaline (0.1-1.7%), salvinorin A (0.1-4.5%), lysergamide (LSA) (0.005-0.4%), harmine (0.04-3.1%), and harmaline (0.008-4.5%) were determined in the 51 products. Although one-third of the products were mixtures of several plant materials or they did not list their ingredients, the raw materials of some products could be estimated by the determination of the typical plant's components. On the other hand, the compounds in some products were not consistent with the ingredients listed on the products. The products which contained raw materials exclusively used as pharmaceuticals were also found to be distributed. Moreover, the contents of the active compounds in some products were sufficient to produce hallucinogenic effects in humans and there is concern about the damage to the health of their users. The proposed analytical method could be useful in the investigation of these plant products in the market.

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