Effects of galacto-oligosaccharides on IgA induction in mammary glands of lactating mice

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  • 泌乳マウスの乳腺における免疫グロブリンA産生に及ぼすガラクトオリゴ糖の影響
  • ヒニュウマウス ノ ニュウセン ニ オケル メンエキ グロブリン A サンセイ ニ オヨボス ガラクト オリゴトウ ノ エイキョウ

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Fifteen ICR pregnant mice were assigned to control or galacto-oligosaccharides (GOS) groups to clarify the effects of GOS on IgA induction in the mammary glands and intestines of lactating mice, and 2.825% GOS was supplemented in the GOS groups from 6.5 days post coitus to 14 days after parturition. Supplemental GOS increased the numbers of IgA-secreting cells and IgA contents in the mammary glands of lactating mice, but the numbers of IgA-secreting cells and IgA contents in the jejunum and ileum of lactating mice were not affected by the treatment. Supplemental GOS had no effect on IgA contents in serum and feces of lactating mice and serum, stomach contents and feces of neonatal mice. Supplemental GOS increased the mRNA expression of CCL25 in the mammary glands of lactating mice. These results imply that supplemental GOS in maternal mice during pregnancy and lactation is effective to increase IgA induction in the mammary glands of lactating mice.

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