rRNA degradation in Bombyx mori and Bombyx mandarina cells infected with heterologous nucleopolyhedroviruses

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  • Hamajima Rina
    Laboratory of Sericulture and Entomoresources, Graduate School of Bioagricultural Sciences, Nagoya University
  • Yasunaga-Aoki Chisa
    Laboratory of Insect Pathology and Microbial Control, Institute of Biological Control, Faculty of Agriculture, Kyushu University
  • Iwanaga Masashi
    Department of Agrobiology and Bioresources, Utsunomiya University
  • Imanishi Shigeo
    Molecular Biomimetics Research Unit, National Agriculture and Food Research organization
  • Kobayashi Jun
    The Graduate School of Sciences and Technology for Innovation, Yamaguchi University
  • Sasaki Kuni
    The United Graduate School of Agricultural Sciences, Tottori University
  • Kusakabe Takahiro
    Laboratory of Insect Genome Science, Kyushu University Graduate School of Bioresource and Bioenvironmental Sciences
  • Man Lee Jae
    Laboratory of Insect Genome Science, Kyushu University Graduate School of Bioresource and Bioenvironmental Sciences
  • Mon Hiroaki
    Laboratory of Insect Genome Science, Kyushu University Graduate School of Bioresource and Bioenvironmental Sciences
  • Kobayashi Michihiro
    Laboratory of Sericulture and Entomoresources, Graduate School of Bioagricultural Sciences, Nagoya University
  • Ikeda Motoko
    Laboratory of Sericulture and Entomoresources, Graduate School of Bioagricultural Sciences, Nagoya University

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  • rRNA degradation in <i>Bombyx mori</i> and <i>Bombyx mandarina</i> cells infected with heterologous nucleopolyhedroviruses

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We previously found that rRNA of BM-N cells derived from the silkworm Bombyx mori undergoes rapid and extensive degradation through site-specific cleavage during abortive infection with nucleopolyhedroviruses (NPVs) of Autographa californica (AcMNPV), Hyphantria cunea (HycuMNPV), Spodoptera exigua and S. litura. Here, we demonstrated that rRNA degradation also occurs in Bme21 and Bm-aff3 cells, which are derived from B. mori embryo and fat body, respectively, during infection with AcMNPV. rRNA degradation in Bme21 cells was also observed following HycuMNPV infection, but was not detected in Bm-aff3 cells. We further showed that rRNA in a cell line derived from B. mandarina, an ancestor of B. mori, underwent degradation in response to cellular infection with AcMNPV and HycuMNPV. In contrast, no rRNA degradation was observed in a cell line derived from Antheraea pernyi. Taken together, these results indicate that NPV-triggered rRNA degradation represents a mechanism of innate antiviral immunity that is unique to B. mori and B. mandarina cells.<br>

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