ウシにおけるアンピシリン坐剤の吸収性

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タイトル別名
  • Rectal Absorption of Ampicillin Suppository in Cattle
  • ウシ ニ オケル アンピシリン ザザイ ノ キュウシュウセイ

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A study was carried out to evaluate experimentally the rectal absorption of ampicillin (ABPC) suppository in cattle, using 24 adult cattle weighing 411-639kg. The animals were divided randomly into three groups. Group I (Control): ABPC Na was administered intramuscularly at a dose of 10mg/kg b. w., which is the accepted dosage for large animals. Group II: ABPC suppository containing no absorption promoters was administered rectally at a dose of 20mg ABPC Na/kg b. w.. Group III: ABPC suppository containing 10w/w% of sodium caprate as a rectal absorption promoter was administered rectally at a dose of 20mg ABPC Na/kg b. w.. Pharmacokinetic parameters were measured after administration in all three groups. The occurrence of systemic and local adverse reactions was not observed after administration in groups II and III. The highest serum concentrations in groups I, II and III were 12.83±4.51μg/ml at 30 min, 2.43±1.48μg/ml at 30min and 8.83±3.70μg/ml at 45min, respectively. The peak concentrations and the time of peak concentrations in group I, II and III were 13.96±3.61μg/ml and 0.72± 0.20h, 2.80±1.25μg/ml and 0.66±0.21h and 9.63±4.56μg/ml and 0.78±0.15h, respectively. By the addition of the absorption promoter, absorption of ABPC from the suppositories was increased about 3.5-fold and about two-thirds to approximately equal the absorption after intramuscular injection. The serum concentrations of ABPC in Group III were well above the minimum inhibitory concentration values for the most common pathogens of infection in cattle. No adverse reaction was observed in any of the experimental groups. These results suggest that rectal administration of ABPC is a safe and effective treatment for bacterial infections in cattle.

収録刊行物

  • 日本畜産学会報

    日本畜産学会報 66 (11), 969-975, 1995

    公益社団法人 日本畜産学会

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