Magnetic Susceptibility Changes in the Basal Ganglia and Brain Stem of Patients with Wilson’s Disease: Evaluation with Quantitative Susceptibility Mapping
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- Doganay Selim
- Pediatric Radiology, Faculty of Medicine, Erciyes University
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- Gumus Kazim
- Biomedical Imaging Research Center, Erciyes University
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- Koc Gonca
- Pediatric Radiology, Faculty of Medicine, Erciyes University
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- Bayram Ayse Kacar
- Pediatric Neurology, Faculty of Medicine, Erciyes University
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- Dogan Mehmet Sait
- Pediatric Radiology, Faculty of Medicine, Erciyes University
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- Arslan Duran
- Pediatric Gastroenterology, Faculty of Medicine, Erciyes University
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- Gumus Hakan
- Pediatric Neurology, Faculty of Medicine, Erciyes University
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- Gorkem Sureyya Burcu
- Pediatric Radiology, Faculty of Medicine, Erciyes University
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- Ciraci Saliha
- Pediatric Radiology, Faculty of Medicine, Erciyes University
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- Serin Halil Ibrahim
- Radiology Department, Faculty of Medicine, Bozok University
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- Coskun Abdulhakim
- Pediatric Radiology, Faculty of Medicine, Erciyes University
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説明
<p>Objectives: Wilson’s disease (WD) is characterized with the accumulation of copper in the liver and brain. The objective of this study is to quantitatively measure the susceptibility changes of basal ganglia and brain stem of pediatric patients with neurological WD using quantitative susceptibility mapping (QSM) in comparison to healthy controls.</p><p>Methods: Eleven patients with neurological WD (mean age 15 ± 3.3 years, range 10–22 years) and 14 agematched controls were prospectively recruited. Both groups were scanned on a 1.5 Tesla clinical scanner. In addition to T1- and T2-weighted MR images, a 3D multi-echo spoiled gradient echo (GRE) sequence was acquired and QSM images were derived offline. The quantitative measurement of susceptibility of corpus striatum, thalamus of each hemisphere, midbrain, and pons were assessed with the region of interest analysis on the QSM images. The susceptibility values for the patient and control groups were compared using twosample t-test.</p><p>Results: One patient with WD had T1 shortening in the bilateral globus pallidus. Another one had hyperintensity in the bilateral putamen, caudate nuclei, and substantia nigra on T2-weighted images. The rest of the patients with WD and all subjects of the control group had no signal abnormalities on conventional MR images. The susceptibility measures of right side of globus pallidus, putamen, thalamus, midbrain, and entire pons were significantly different in patients compared to controls (P < 0.05).</p><p>Conclusion: QSM method exhibits increased susceptibility differences of basal ganglia and brain stem in patients with WD that have neurologic impairment even if no signal alteration is detected on T1- and T2-weighted MR images.</p>
収録刊行物
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- Magnetic Resonance in Medical Sciences
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Magnetic Resonance in Medical Sciences 17 (1), 73-79, 2018
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