Effects of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) on the Release of Growth Hormone (GH), Luteinizing Hormone (LH), and Prolactin (PRL) from Cultured Bovine Anterior Pituitary Cells In Vitro

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  • 培養牛下垂体前葉細胞からの成長ホモン(GH),黄体形成ホルモン(LH)およびプロラクチン(PRL)の放出に及ぼすPituitary Adenylate Cyclase-Activating Polypeptide (PACAP)の効果
  • バイヨウ ウシ カスイタイ ゼンヨウ サイボウ カラ ノ セイチョウ ホルモン

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Abstract

The effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on the release of growth hormone (GH), luteinizing hormone (LH), and prolactin (PRL) were studied in cultured bovine anterior pituitary cells in vitro. PACAP significantly increased the release of GH compared with controls at the concentrations of 10-9, 10-8 and 10-7M by 29% (P<0.05), 51% (P<0.05) and 79% (P<0.01), respectively. The PACAP significantly increased the release of LH compared with controls at the concentrations of 10-10, 10-9, 10-8, and 10-7M by 26%, 37%, 65%, and 137%, respectively, (P<0.01). In contrast to the results for GH and LH, PACAP had no effect on the release of PRL. The elevations of both GH and LH induced by PACAP were in a dose-dependent manner (P<0.01). These results suggest that PACAP stimulates the release of GH and LH by acting directly on bovine pituitary cells in vitro.

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