書誌事項
- タイトル別名
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- Immunopotentiation-mediated antitumor activities of sulfated polysaccharides, ascophyllan and fucoidan, isolated from brown alga <i>Ascophyllum nodosum </i>
- 大型褐藻類Ascophyllum nodosumから精製された硫酸基含有多糖体アスコフィラン及びフコイダンの免疫賦活作用を介した抗腫瘍効果
- オオガタ カッソウルイ Ascophyllum nodosum カラ セイセイサレタ リュウサンキ ガンユウ タトウタイ アスコフィラン オヨビ フコイダン ノ メンエキ フカツ サヨウ オ カイシタ コウシュヨウ コウカ
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説明
Ascophyllan and fucoidan, fucose-containing sulfated polysaccharides isolated from brown seaweed Ascophyllum nodosum, have various biological activities in vitro. Our previous studies have demonstrated that these polysaccharides induce tumor necrosis factor-α (TNF-α) and granulocyte-colony stimulating factor (G-CSF) secretion from murine macrophage cell line, RAW264.7 cells in a concentration-dependent manner. In this study, we investigated in vivo effects of ascophyllan and fucoidan in mouse model in addition to in vitro studies. In Sarcoma180 ascites tumor-bearing mouse model, the increases in the survival rate of tumor-bearing mouse treated with intraperitoneal (i.p.) administration of ascophyllan and fucoidan were observed as compared to the control mouse injected with saline alone. Since ascophyllan and fucoidan showed no significant cytotoxicity on Sarcoma 180 cells in vitro, these polysaccharides may suppress tumor growth through the activation of host immune system rather than a direct cytotoxic effect on tumor cells. In fact, i.p. injection of ascophyllan and fucoidan into mouse resulted in significant increase in the serum levels of TNF-α and G-CSF.
収録刊行物
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- 日本食品化学学会誌
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日本食品化学学会誌 18 (2), 83-91, 2011
日本食品化学学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390282680173303936
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- NII論文ID
- 110008897460
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- NII書誌ID
- AA11666400
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- ISSN
- 21896445
- 13412094
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- NDL書誌ID
- 11250732
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可