Effects of Benzoyl Peroxide on the Cardiovascular Systems

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  • 過酸化ベンゾイルの循環器系に及ぼす影響
  • カサンカ ベンゾイル ノ ジュンカンキケイ ニ オヨボス エイキョウ

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Abstract

Effects of benzoyl peroxide on the cardiovascular systems in rats were investigated. The results obtained in the present study were as follows: (1) Benzoyl peroxide did not affect the contractile force and beating rate in the atria isolated from rats. (2) Benzoyl peroxide at a concentration of 10-5g/ml significantly depressed the contractile responses to noradrenaline and relaxation responses to acetylcholine in the isolated aorta of rats as shown the figure. (3) Benzoyl peroxide at a concentration of 10-5g/ml did not significantly affect the contractile responses to noradrenaline and relaxation responses to acetylcholine in the isolated mesenteric artery of rats. (4) Benzoyl peroxide did not affect the blood pressure and heart rate of rat in in vivo. [figure] Fig. 10 Effects of benzoyl peroxide (0.01mg/ml) on contraction to noradrenaline (NA: left panel) and relaxation to acetylcholine (ACh: right panel) in rat aorta These results indicate that benzoyl peroxide at higher concentration depressed the contractile and relaxing function of vascular smooth muscles. Therefore, the present results suggest that excess benzoyl peroxide may change some physiological functions of smooth muscle tissue.

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