書誌事項
- タイトル別名
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- Effects of Parathyroid Hormone and Calcitonin on Kinetics of Actin Filaments in Chicken Osteoclasts of Cultured Medullary Bone
- Effects of Parathyroid Hormone and Calc
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抄録
Medullary bones dissected from hen femurs at 3 hours (when osteoclasts cease bone resorption) and 12 hours (when osteoclasts actively resorb bone) after oviposition were cultured in BGJb media containing synthetic human parathyroid hormone (PTH) and synthetic eel calcitonin (CT), respectively, and the effects of PTH and. CT on the distributional patterns of actin filaments in the medullary bone osteoclasts were observed. Three hours after oviposition, the osteoclasts displayed strong fluorescence of actin filaments in the form of amorphous bands in the apical region of the cytoplasm, corresponding to clear zones. There was no change in the distributional patterns of actin filaments in osteoclasts after culturing without PTH for 24 hours. However, after culturing with PTH for 24 hours, central parts of the actin bands in the osteoclasts became obscure, and the osteoclasts displayed actin filaments as linear forms perpendicular to the bone surface. On the other hand, 12 hours after oviposition, actin filaments appeared as lines perpen-dicular to the bone surface in the apical region of the cytoplasm, where ruffled borders had developed. There was no change in the distributional patterns of actin filaments in osteoclasts after culturing without CT for 24 hours. However, after culturing with PTH for 24 hours, the linear actin filaments disappeared and the osteoclasts displayed amorphous bands of actin filaments in the apical region of the cytoplasm. These results suggested that PTH and CT would regulate osteoclastic bone resorption by modifying the organization of actin filaments in osteoclasts.
収録刊行物
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- 日本畜産学会報
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日本畜産学会報 67 (6), 526-532, 1996
公益社団法人 日本畜産学会
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詳細情報 詳細情報について
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- CRID
- 1390282680173546752
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- NII論文ID
- 10024583882
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- NII書誌ID
- AN00195188
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- ISSN
- 18808255
- 00215309
- 1346907X
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- NDL書誌ID
- 3986972
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
