Effect of dietary supplementation of sea cucumbers product on hepatic regeneration in rat

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  • Ono Kaname
    Department of Food and nutrition Shokei University Junior College
  • Kawai Wakana
    Graduate School of Science and Technology, Nagasaki University
  • Miyazaki Riho
    Graduate School of Fisheries Science and Environmental studies, Nagasaki University
  • Hirasaka Katsuya
    Graduate School of Fisheries Science and Environmental studies, Nagasaki University
  • Taniyama Shigeto
    Graduate School of Fisheries Science and Environmental studies, Nagasaki University
  • Tachibana Katsuyasu
    Graduate School of Fisheries Science and Environmental studies, Nagasaki University

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Other Title
  • 乾燥ナマコの投与がラットの実験的肝再生に及ぼす影響
  • カンソウ ナマコ ノ トウヨ ガ ラット ノ ジッケンテキ カン サイセイ ニ オヨボス エイキョウ

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We examined the effect of dietary sea cucumber on hepatic regeneration in rat. Wistar rats were fed either a normal or an sea cucumbers diet containing 1 or 5% dried sea cucumber for 5 days. The nutrients composition of the dried sea cucumber per 100 g was moisture 8.3 g, crude protein 51.0 g, crude fat 1.9 g, carbohydrate 13.7 g, and ash 25.1 g, which contins salinity concentration of 24.0%, respectevely. The amount of total free amino acid was 353.0 mg, including a large amount of tauline. After 70% partial hepatectomy, we porformed biochemical analysis and histological analysis by using electric microscopy in the regenerating liver in rats. The total protein content in liver of rats fed the sea cucumber diet was signifcanlty higher than that of normal diet. In liver tissue observation, the acid phosphatase activity of the sea cucumber diet group was higher than that of the control group. Moreover, the secondary lysosomes and lipid droplets as observed in the regeneratin liver was found in liver of rats fed the sea cucumber diet. These results suggest that dietary sea cucumber improve hepatic regeneration in rat.

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