Efficacy and Safety of Selamectin Topical Formulation in the Treatment of Flea and Ear Mite Infestations in Japan

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  • セラメクチン滴下型経皮投与剤の有効性および安全性：ネコにおけるノミおよびミミヒゼンダニの駆除

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To assess the efficacy and safety of selamectin topical formulation, clinical studies were conducted using 192 cats in total presented at veterinary clinics in Japan. In the studies, cats received a unit dose in the basis of 6 mg selamectin per kg of body weight. In this study, efficacy rates in elimination of flea infestation (percentages of infestation-negative animals) on Day 30 after the treatment were 57% (n=96) in the selamectin-treatment group, and 19% (n=27) in the fenthion-treatment group. By the subsequent monthly treatment for the purpose of prevention from new flea infestation, the prevention rates on Day 60 and 90 were 81% and 92% in the selamectin-treatment group, and 46% and 35% in the fenthion-treatment group, respectively. The efficacies in two groups were significantly different on each day. In the study on ear mites, the efficacy rate of treatment on Day 30 was 96.1% (n=51) in the selamectin-treatment group, and 37.5% (n=8) in the rotenone/areslin-treatment group. The efficacies in two groups were significantly different. No severe adverse events were observed in all cats examined. In conclusion, a topical unit dose in the basis of 6 mg selamectin per kg of body weight is effective and safe in the treatment of flea and ear mite infestations. The monthly application for 3 times prevented new flea infestation in more than 90% of cats.

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